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| Cat. Number | SN-6 |
| Chemical Name | SN-6 |
| CAS Number | [415697-08-4] |
| Mol. Formula | C20H22N2O5S |
| Mol. Weight | 402.16 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2-[[4-[(4-Nitrophenyl)methoxy]pheny l]methyl]-4-thiazolidinecarboxylic acid ethyl ester |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Desiccate at +4°C |
| References | Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM). |
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