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| Cat. Number | SKI II |
| Chemical Name | SKI II |
| CAS Number | [312636-16-1] |
| Mol. Formula | C15H11ClN2OS |
| Mol. Weight | 302.78 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 4-[[4-(4-Chlorophenyl)-2-thiazolyl] amino]phenol |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at -20°C |
| References | Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM). Purity: >98 % |
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