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| Cat. Number | SK1-I |
| Chemical Name | SK1-I |
| CAS Number | [1072443-89-0] |
| Mol. Formula | C17H27NO2.HCl |
| Mol. Weight | 313.86 |
| Qty 1 |
10mg |
| Synonym | 1,2,4-Trideoxy-4-(methylamino)-1-(4 -pentylphenyl)-D-erythro-pent-1-enitol hydrochloride |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage condition | Store at -20°C |
| References | Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines. Purity: >98 % |
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