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| Cat. Number | TPCA-1 |
| Chemical Name | TPCA-1 |
| CAS Number | [507475-17-4] |
| Mol. Formula | C12H10FN3O2S |
| Mol. Weight | 279.29 |
| Qty 1 |
10mg |
| Synonym | 2-[(Aminocarbonyl)amino]-5-(4-fluor ophenyl)-3-thiophenecarboxamide |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Storage condition | Desiccate at -20°C |
| References | Potent, selective inhibitor of IκB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory. Purity: >97 % |
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