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| Cat. Number | TAK 165 |
| Chemical Name | TAK 165 |
| CAS Number | [366017-09-6] |
| Mol. Formula | C25H23F3N4O2 |
| Mol. Weight | 468.47 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 1-[4-[4-[[2-[(1E)-2-[4-(trifluorome thyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]but yl]-1H-1,2,3-triazole |
| Solubility | Soluble to 75 mM in DMSO and to 5 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. Purity: >99 % |
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