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| Cat. Number | T 0901317 |
| Chemical Name | T 0901317 |
| CAS Number | [293754-55-9] |
| Mol. Formula | C17H12F9NO3S |
| Mol. Weight | 481.33 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | N-(2,2,2-Trifluoroethyl)-N-[4-[2,2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phe nyl]benzenesulfonamide |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LRXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Purity: >98 % |
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