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/ Products Classification 点击展开+Cat. Number | WHI-P 154 |
Chemical Name | WHI-P 154 |
CAS Number | [211555-04-3] |
Mol. Formula | C16H14BrN3O3 |
Mol. Weight | 376.2 |
Qty 1 |
10mg |
Qty 2 | 50mg |
Synonym | 2-Bromo-4-[(6,7-dimethoxy-4-quinazo linyl)amino]phenol |
Solubility | Soluble to 100 mM in DMSO |
Storage condition | Store at RT |
References | JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Purity: >99 % |