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Cat. Number
HW5769
Chemical Name
Wortmannin
CAS Number
[19545-26-7]
Mol. Formula
C23H24O8
Mol. Weight
428.43
Qty 1
1mg
Qty 2
5mg
Application Notes
97%
Synonym
Wartmannin
Melting Pt.
240°C
Solubility
Soluble in methanol and DMSO
Storage condition
-20°C
References

Boulton S, Kyle S, Yalcintepe L, Durkacz BW. Carcinogenesis. 17 : 2285 -90 (1996). Ng SSW, Tsao MS, Chow S, Hedley DW. Cancer Res. 60: 5451-5 (2000). Kubota N, Okada S, Inada T, Ohnishi K, Ohnishi T. Cancer Lett. 161:141-7 (2000).

Wortmannin is an inhibitor of PI3-K and DNa-dependent protein kinase, which is known to mediate DNA double strand break repair. It induces apoptosis and also sensitize cells to ionizing radiation.

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