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Cat. Number
188834999652973
Chemical Name
依立替康 Irinotecan
CAS Number
[136572-09-3]
Mol. Formula
C33H38N4O6.HCl.3H2O
Mol. Weight
677.20
Qty 1
5mg
Appearance
Yellow Crystalline Powder
Application Notes
A DNA topoisomerase inhibitor
Synonym
(7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin hydrochloride);U 10144OE;Camptothecin 11 hydrochloride
Melting Pt.
222-223℃
Solubility
Slightly soluble in methanol or water.
Storage condition
+4°C
References

A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer. [Camptosar, 7-ethyl-10-hydroxycamptothecin, CPT-11]
 

Irinotecan           
Purity:  ≥98% (HPLC)         
规   格：100mg  / 瓶          1920 RMB          上海库存       >10    
其它名称: Irinotecan Hydrochloride, S-Form
Irinotecan, Hydrochloride
[1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride (9CI)
1H-Pyrano[3',4':6,7]indolizino[1,2- b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv
(S)-([1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, (S)-)
(7-Ethyl- 10-[[4-(1-piperidyl)-1-piperidyl]carbonyloxy]camptothecin hydrochloride)
([1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride (1:1))
U 101440E
Topotecin hydrochloride
Camptosar
Irinotecan
7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin
Camptothecin-11
(1,4'-Bipiperidine)-1'-carboxylic acid, 3,4,12,14-tetrahydro-4,11-diethyl-4-hydroxy-3,4-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, (S)-
Campto
Camptothecin 11 hydrochloride
CPT 11
7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin hydrochloride
Irinotecan hydrochloride
Topotecin
U 10144OE
下一个：TKI7074上一个：TKI6068
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