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Cat. Number
733985656446181
Chemical Name
Ruboxistaurin Hydrochloride
CAS Number
169939-93-9
Category
Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C28H29ClN4O3
Mol. Weight
505.01
Qty 1
25mg
Application Notes
Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications.
Synonym
(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride; LY 333531;
References

Ruboxistaurin hydrochloride 是一种选择性的,ATP-竞争性的 PKCβ 抑制剂

Miller, J., et al.: Diabetes Metab. Rev., 13, 37 (1997),
Suzuma, I., et al.: J. Biol. Chem., 277, 1047 (2002),
Ali, N., et al.: J. Pharmacol. Sci., 98, 130 (2005),
 

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