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Cat. Number
733985627118699
Chemical Name
Regorafenib
CAS Number
755037-03-7
Category
Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C21H15ClF4N4O3
Mol. Weight
482.82
Qty 1
2.5mg
Qty 2
25mg
Application Notes
It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Synonym
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-[N’-(4-Chloro-3-trifluoromethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid Methylamide;
References
Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),
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