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Cat. Number
733985602802538
Chemical Name
cis R-138727, (Prasugrel Metabolite) (Mixture of Diastereomers) Discontinued
CAS Number
204204-73-9
Category
Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol. Formula
C18H20FNO3S
Mol. Weight
349.42
Application Notes
The active metabolite of Prasugrel (咨询); inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: influence of other blood cells, calcium, and aspirin.
Synonym
(2Z)-2-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic Acid; R 138727;
References

 

Ekins, S., et al.: J. Pharmacol. Exp. Ther., 286, 1253 (1998),
Lamba, V., et al.: J. Pharmacol Exp. Ther., 307, 906 (2003),
Yoneda, K., et al.: Br. J. Pharmacol., 142, 551 (2004),
Jakubowski, J., et al.: J. Cardiovasc. Pharmacol., 47, 377 (2006),
Rehmel, J., et al.: Drug Metab. Dispos., 34, 600 (2006),

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