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/ Products Classification 点击展开+Cat. Number | 733983961210894 |
Chemical Name | (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin
-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine |
CAS Number | 767340-03-4 |
Category | Inhibitors, Heterocycles, Intermediates, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, |
Mol. Formula | C16H13F6N5O |
Mol. Weight | 405.30 |
Qty 1 |
5mg |
Qty 2 | 50mg |
Appearance | White Solid |
Application Notes | Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension. |
Synonym | (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one; 2,3-Desdihydrogen rac-Sitagliptin |
Melting Pt. | 178-180°C |
Solubility | DMSO, Methanol |
Storage condition | Refrigerator |
References | Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006) |