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/ Products Classification 点击展开+| Cat. Number | 733980705420530 |
| Chemical Name | Leflunomide-d4 |
| Category | Aromatics, Heterocycles, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Inhibitors, |
| Mol. Formula | C12H5D4F3N2O2 |
| Mol. Weight | 274.23 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Appearance | Off White Crystalline Solid |
| Application Notes | An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. |
| Synonym | 5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]-d4; Leflunomida-d4; 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide-d4; Leflunomidum-d4; |
| Melting Pt. | 161-163°C |
| Solubility | Dichloromethane, Ether, Ethyl Acetate, Methanol |
| References | Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009), |
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