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/ Products Classification 点击展开+| Cat. Number | 733979406692009 |
| Chemical Name | Indirubin-3’-monoxime |
| CAS Number | 160807-49-8 |
| Category | Inhibitors |
| Mol. Formula | C16H11N3O2 |
| Mol. Weight | 277.28 |
| Qty 1 |
5mg |
| Qty 2 | 50mg |
| Appearance | Dark Red Solid |
| Application Notes | A potent inhibitor of GSK-3? (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM). |
| Synonym | Indirubin-3’-oxime; 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one;
|
| Melting Pt. | 247-249°C |
| Solubility | DMSO, Methanol |
| Storage condition | -20?C Freezer |
| Stability | Light Sensitive |
| References | Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Damiens, E., et al.: Oncogene, 20, 3786 (2001), Marko, D., et al.: Br. J. Cancer, 84, 283 (2001) |
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