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| Cat. Number | 733977952195092 |
| Chemical Name | 5-Fluoroorotic Acid, Monohydrate |
| CAS Number | 703-95-7 |
| Category | Nucleotides, Bases & Related Reagents, 5-FOA |
| Mol. Formula | C5H5FN2O5 |
| Mol. Weight | 192.1 |
| Qty 1 |
1g |
| Qty 2 | 5g |
| Appearance | White to Off-White Crystalline Solid |
| Application Notes | 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents. |
| Synonym | 5-FOA |
| Melting Pt. | 285-290°C dec. |
| Solubility | 50mg in 1ml (1:1 Ammonium Hydroxide:Water) with Gentle Heating |
| Storage condition | -20°C Freezer |
| References | ############################################################################################################################################################################################################################################################### |
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