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Cat. Number
733977697147361
Chemical Name
Flavopiridol Hydrochloride
CAS Number
131740-09-5
Category
Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C21H21Cl2NO5
Mol. Weight
438.30
Qty 1
10mg
Qty 2
100mg
Appearance
Yellow Solid
Application Notes
An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.
Synonym
rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride; Alvocidib Hydrochloride; HL 275; MDL 107826A; NSC 649890;
Melting Pt.
183-187?C
Solubility
DMSO, Methanol
Storage condition
-20°C Freezer
References

Senderowicz, A.M., et al.: J. Clin. Oncol., 16, 2986 (1998),
Thomas, J.P., et al.: Cancer Chemother. Pharmacol., 50, 465 (2002),
Raju, U., et al.: Cancer Res., 63, 3263 (2003),
Pumfery, A., et al.: Curr. Pharm. Des., 12, 1949 (2006),

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