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Cat. Number
733973534405395
Chemical Name
8-Cyclopentyl-1,3-dipropylxanthine
CAS Number
102146-07-6
Category
Heterocycles, Inhibitors, Neurochemicals
Mol. Formula
C16H24N4O2
Mol. Weight
304.39
Qty 1
100mg
Qty 2
1g
Appearance
White Solid
Application Notes
DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist.
Synonym
8-Cyclopentyl-3,9-dihydro-1,3-dipropyl-1H-purine-2,6-dione; DPCPX, PD 116,948
Melting Pt.
191-194°C
Solubility
DMSO (3.6 mg/ml), Ethanol (4 mg/ml), 0.1N Sodium Hydroxide (2 mg/ml)
Stability
Store tightly sealed at RT; Solutions at 4 deg C for several days
References
Gessi, S., et al.: Mol. Pharmacol., 67, 2137 (2005), Minor, T.R., et al.: Behav. Neurosci., 122, 1236 (2008), Gracia, E., et al.: J. Neurochem., 107, 161 (2008), Gessi, S., et al.: Biochem. Pharmacol., 75, 562 (2008),
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