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/ Products Classification 点击展开+| Cat. Number | 733971536975348 |
| Chemical Name | (R)-(-)-Camptothecin |
| CAS Number | 110351-92-3 |
| Category | Chiral Reagents, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, |
| Mol. Formula | C20H16N2O4 |
| Mol. Weight | 348.35 |
| Qty 1 |
10mg |
| Application Notes | Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent. |
| Synonym | (R)-4-Ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (R)-(-)-Camptothecine; (R)-Camptothecin; 20R-Camptothecin; |
| References | Potmesil, M., et al.: Cancer Res., 54, 1431 (1994), Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997), Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998), Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998), |
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