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Cat. Number
733968135419747
Chemical Name
Amonafide
CAS Number
69408-81-7
Category
Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C16H17N3O2
Mol. Weight
283.33
Qty 1
10mg
Qty 2
100mg
Application Notes
Amonafide is a DNA intercalator and topoisomerase II inhibitor in clinical development for the treatment of neoplastic diseases. Antitumor agent.
Synonym
5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione; FA 142; M-FA 142; MADE-FA 142; NCI 308847; NSC 308847; Nafidimide;
References
Hsiang, Y., et al.: Mol. Pharmacol., 36, 371 (1989), Costanza, M., et al.: Clin. Cancer Res., 1, 699 (1995), Innocenti, F., et al.: Drug Metab. Dispos., 29, 596 (2001), Brana, M., et al.: J. Med. Chem., 47, 1391 (2004),
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