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/ Products Classification 点击展开+| Cat. Number | 733967581602297 |
| Chemical Name | 17-(Allylamino) Geldanamycin |
| CAS Number | 75747-14-7 |
| Category | Amines, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol. Formula | C31H43N3O8 |
| Mol. Weight | 585.69 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Appearance | Dark Purple Solid |
| Application Notes | Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
|
| Synonym | 17-Demethoxy-17-(2-propenylamino)geldanamycin; 17-(Allylamino)-17-demethoxygeldanamycin; 17-(Allylamino)-17-desmethylgeldanamycin; 17-Demethoxy-17-allylaminogeldanamycin; 17AAG; CP 127374; KOS 953; NSC 330507; Tanespimycin; |
| Melting Pt. | 201-203°C |
| Solubility | DMSO, Methanol |
| Storage condition | -20?C Freezer, Under Inert Atmosphere |
| References | Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002), |
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